You spend a lot of money on them but not might see a lot of payback. With people trying to retain their youthful looks, wrinkle creams are a big industry. But not all of the creams available are actually effective. Following extensive research, lab tests and surveys with testers, Good Housekeeping magazine says the top three wrinkle creams are SkinCeuticals Metacell Renewal B3, Clinique Smart Custom-Repair Serum and Boots No7 Protect & Perfect Intense Advanced Serum. Why do these creams rank at the top compared to thousands of others? Tests and reviews say that they are the best at reducing the look of wrinkles and lines in the least amount of time, reducing discoloring of skin and pore size, smoothing the skin's texture and improving skin tone.